Senescence Model Development
As we age we are more susceptible to a range of age-related diseases. Dysregulation of normal cellular processes can drive unhealthy...
Gristleball - University of Exeter Images of Research Submission
This photograph shows a sphere of cartilage cells grown in our lab. The cells are stained for a biomarker of cellular ageing in red and...
Reusable glassware for routine cell culture—a sterile, sustainable and affordable alternative to single-use plastics
Cell culture is a cornerstone of in vitro biological research. Whilst glassware was once commonplace in tissue culture facilities, in...
An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture
The likelihood that potential new drugs will successfully navigate the current translational pipeline is poor, with fewer than 10% of...
Image Analysis Using the Fluorescence Imaging of Nuclear Staining (FINS) Algorithm
Finding appropriate image analysis techniques for a particular purpose can be difficult. In the context of the analysis of...
Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones
Repurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency...
Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer
Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a hallmark of cancer that profoundly...
Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes
Progeroid syndromes such as Hutchinson Gilford Progeroid syndrome (HGPS), Werner syndrome (WS) and Cockayne syndrome (CS), result in...
Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence
The human genome is capable of producing hundreds of thousands of different proteins and non-coding RNAs from <20 000 genes, in a...
An evaluation of the role of miR-361-5p in senescence and systemic ageing
Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery...