How ‘animal methods bias’ is affecting research careers - A Nature Careers feature
Christine Ro has recently interviewed various researchers, including Team RNA's Dr Laura Sinclair, to further understand how the use of...
The Role of RNA-Binding Proteins in Maintaining Cell Identity and Shaping Stress Responses
The human body is full of specialised cells, each with unique patterns of gene expression that allow them to accomplish unique functions....
An Evaluation of Naturally Occurring Plant-based Sex Hormone Mimetics as Senotherapeutic Drug Candidates
Women tend to live longer than men and have less susceptibility to age-related diseases up until menopause. The cellular mechanisms that...
An Evaluation of Retained intron splicing event as Therapeutic Target in Prostate Cancer
Previously in our team, Mou et al. carried out a comprehensive analysis of splicing patterns in three different prostate data sets. The study identified the reduced expression of a retained intron in a mitosis and chromosome segregation regulator as a single common factor among the tested sets, which correlated with poor PCa prognosis. Therefore, this project was designed to evaluate the potential therapeutic role of modifying intron retention expression in PCa. We aim to f
Exploring the Microglial Phenotypic Shift From Neurotropic to Neurotoxic in the Ageing Brain
This research aims to explore the miRNA profiles of exosomes derived from monocyte-derived microglia-like cells to identify key molecules...
A Senotherapeutic Approach to Neurodegenerative Disease
Funded by SENISCA, PhD student Jodie is exploring their portfolio of senotherapeutics as a potential therapeutic intervention for...
Senescence Model Development
As we age we are more susceptible to a range of age-related diseases. Dysregulation of normal cellular processes can drive unhealthy...
Gristleball - University of Exeter Images of Research Submission
This photograph shows a sphere of cartilage cells grown in our lab. The cells are stained for a biomarker of cellular ageing in red and...
Reusable glassware for routine cell culture—a sterile, sustainable and affordable alternative to single-use plastics
Cell culture is a cornerstone of in vitro biological research. Whilst glassware was once commonplace in tissue culture facilities, in...
An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture
The likelihood that potential new drugs will successfully navigate the current translational pipeline is poor, with fewer than 10% of...