July 10, 2019

This research follows on from some of our earlier work on alternative RNA splicing, and builds on our findings that the regulators of the splicing machinery (splicing factors) associate with ageing and lifespan.

For this study, we used a human "healthy ageing" cohort st...

May 17, 2019

Work using mice and rats has shown that when exposed to the kinds of physiological conditions seen in a person with type 2 diabetes, the insulin producing beta cells are losing their ability to produce insulin because they are either reverting to earlier cell types or...

December 4, 2017

Our results suggest that modification of splicing factor expression has the potential to influence cell senescence phenotypes and could represent a promising target for interventions designed to improve health span in the future

  Age is the main risk factor for mostly...

August 17, 2016

This research thread focuses on the role of RNA regulation in ageing and longevity in mammals.  We are currently investigating two aspects of this regulation in depth.

Firstly, we are looking at alternative RNA splicing.  This is a highly important process which contrib...

August 4, 2016

Type 2 Diabetes affects 415 million people world-wide and is characterised by chronic high blood sugar (hyperglycaemia) and insulin resistance, progressing to insufficient insulin production. This occurs due to failure of the insulin producing beta cells in the pancrea...

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