“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

PUBLICATIONS

- Claude Bernard -

2024

Trusler EC, Davies M, Spurrier B, Gould SJ (2024). Reusable glassware for routine cell culture—a sterile, sustainable and affordable alternative to single-use plastics. Front. Sustain., 5:1447236. Author URL.

Bramwell LR, Gould SJ, Davies M, McMullan C, Trusler EC, Harries LW (2024). An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture. Altern Lab Anim, 52: 247-260. Author URL.

Bramwell LR, Spencer J, Frankum R, Manni E, Harries LW (2024). Image Analysis Using the Fluorescence Imaging of Nuclear Staining (FINS) Algorithm. J Digit Imaging. Inform. med. Author URL.

Bramwell LR, Frankum R, Harries LW (2024). Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones. Cells, 13(6), 517. Author URL.

2023

Mou Z, Spencer J, McGrath JS, Harries LW (2023). Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer. Human Genomics, 17, 97. Author URL.

Bramwell LR, Harries LW (2023). Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes. GeroScience, Sep 26. doi: 10.1007/s11357-023-00933-z. Epub ahead of print. Author URL.

Harries LW (2023). Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence. FEBS J, 290(5), 1221-1234. Author URL.

Manni E, Jeffery N, Chambers D, Slade L, Etheridge T, Harries LW (2023). An evaluation of the role of miR-361-5p in senescence and systemic ageing. Experimental Gerontology, 174, 112127-112127. Author URL.

Kennedy NA, Janjua M, Chanchlani N, Lin S, Bewshea C, Nice R, McDonald TJ, Auckland C, Harries LW, Davies M, et al (2023). Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic. Gut, 72(2), 295-305. Author URL.

2022

Frankum R, Jameson TSO, Knight BA, Stephens FB, Wall BT, Donlon TA, Torigoe T, Willcox BJ, Willcox DC, Allsopp RC, et al (2022). Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels. Geroscience, 44(2), 1169-1170. Author URL.

Mou Z, Spencer J, Knight B, John J, McCullagh P, McGrath JS, Harries LW (2022). Gene expression analysis reveals a 5-gene signature for progression-free survival in prostate cancer. Frontiers in Oncology, 12. Author URL.

Davies M, Bramwell LR, Jeffery N, Bunce B, Lee BP, Knight B, Auckland C, Masoli JA, Harries LW (2022). Persistence of clinically relevant levels of SARS-CoV2 envelope gene subgenomic RNAs in non-immunocompromised individuals. Int J Infect Dis, 116, 418-425. Author URL.

2021

Jeffery N, Chambers D, Invergo BM, Ames RM, Harries LW (2021). Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD. Cell & Bioscience, 11(1). Author URL.

Frankum R, Jameson TSO, Knight BA, Stephens FB, Wall BT, Donlon TA, Torigoe T, Willcox BJ, Willcox DC, Allsopp RC, et al (2021). Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels. GeroScience, 44(2), 1169-1170. Author URL.

Lee BP, Harries LW (2021). Senotherapeutic Drugs: a New Avenue for Skincare?. PLASTIC AND RECONSTRUCTIVE SURGERY, 148(6S), 21S-26S. Author IRL.

Bramwell LR, Harries LW (2021). Targeting Alternative Splicing for Reversal of Cellular Senescence in the Context of Aesthetic Aging. Plast Reconstr Surg, 147(1S-2), 25S-32S. Author URL.

2020

Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries LW, Pilling LC, Melzer D (2020). Erratum: the longevity-associated SH2B3 (LNK) genetic variant: selected aging phenotypes in 379,758 subjects (Journals of Gerontology - Series a Biological Sciences and Medical Sciences DOI: 10.1093/gerona/glz191). Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 75(9). Author URL.

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, et al (2020). The inherent challenges of classifying senescence−−Response. Science, 368(6491), 595-596. Author URL.

This is a response to a letter submitted in response to our policy paper (see below).

Haque S, Ames RM, Moore K, Lee BP, Jeffery N, Harries LW (2020). Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood. BMC Med Genomics, 13(1). Author URL.

Lee BP, Smith M, Buffenstein R, Harries LW (2020). Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation. Geroscience, 42(2), 633-651. Author URL.

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, et al (2020). To help aging populations, classify organismal senescence. Science 2019. Vol. 366, Issue 6465, pp. 576-578. Author URL.

This is a policy paper aiming to classify cellular senescence. Such a classification is necessary before clinical trials for intervention can conducted, a disease can be diagnosed, intervention can be prescribed or treatment can be administered. This is an important first step towards the realising the potential of senotherapeutic approaches to age-related disease.

Haque S, Ames RM, Moore K, Pilling LC, Peters LL, Bandinelli S, Ferrucci L, Harries LW (2020). circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan. Geroscience, 42(1), 183-199. Author URL.

2019

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, et al (2019). To help aging populations, classify organismal senescence. Science, 366(6465), 576-578. Author URL.

Harries L (2019). It's time for scientists to shout about RNA therapies. Nature, 574(7778). Author URL.

Galvis D, Walsh D, Harries LW, Latorre E, Rankin J (2019). A dynamical systems model for the measurement of cellular senescence. Journal of the Royal Society Interface, 16(159). Author URL.

Lee BP, Mulvey L, Barr G, Garratt J, Goodman E, Selman C, Harries LW (2019). Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels. Exp Gerontol, 128. Author URL.

Lye JJ, Latorre E, Lee BP, Bandinelli S, Holley JE, Gutowski NJ, Ferrucci L, Harries LW (2019). Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline. Geroscience, 41(5), 561-573. Author URL.

Jeffery N, Harries LW (2019). miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC-βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways. Exp Cell Res, 384(1). Author URL.

Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW (2019). The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. Biogerontology, 20(5), 649-663. Author URL.

Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW (2019). Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns. Hum Mol Genet, 28(16), 2763-2774. Author URL.

Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, Lee BP, Harries LW (2019). Obesity impacts the regulation of miR-10b and its targets in primary breast tumors. BMC Cancer, 19(1). Author URL.

Latorre E, Ostler EL, Faragher RGA, Harries LW (2019). FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. FASEB J, 33(1), 1086-1097. Author URL.

2018

Harries L, Goljanek-Whysall K (2018). The biology of ageing and the omics revolution. Biogerontology, 19(6), 435-436. Author URL.

Galloway T, Baglin N, Harries LW, Lee BP, Kocur AL, Shepherd M, Steele A, BPA Schools Study Consortium (2018). An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol a (BPA) levels in teenagers. BMJ Open, 8, e018742-e018742. Author URL.

Latorre E, Torregrossa R, Wood ME, Whiteman M, Harries LW (2018). Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2. Aging (Albany NY), 10(7), 1666-1681. Author URL.

Locke JM, Saint-Martin C, Laver TW, Patel KA, Wood AR, Sharp SA, Ellard S, Bellanné-Chantelot C, Hattersley AT, Harries LW, et al (2018). The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in Individuals with HNF1A-MODY. Diabetes, 67(9), 1903-1907. Author URL.

Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW (2018). The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond), 132(3), 313-325. Author URL.

2017

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Author URL.

Pilling LC, Kuo C-L, Sicinski K, Tamosauskaite J, Kuchel GA, Harries LW, Herd P, Wallace R, Ferrucci L, Melzer D, et al (2017). Human longevity: 25 genetic loci associated in 389,166 UK biobank participants. Aging (Albany NY), 9(12), 2504-2520. Author URL.

Haque S, Harries LW (2017). Circular RNAs (circRNAs) in Health and Disease. Genes (Basel), 8(12). Author URL.

Jeffery N, Richardson S, Beall C, Harries LW (2017). The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells. Experimental Cell Research, 361(2), 284-291. Author URL.

Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, et al (2017). Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol, 18(1). Author URL.

Latorre E, Harries LW (2017). Splicing regulatory factors, ageing and age-related disease. Ageing Res Rev, 36, 165-170. Author URL.

Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7. Author URL.

2016

Jeffery N, Harries LW (2016). β-cell differentiation status in type 2 diabetes. Diabetes Obes Metab, 18(12), 1167-1175. Author URL.

Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, et al (2016). Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine, 8, 103-116. Author URL.

Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Author URL.

Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N, et al (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res, 44(13), 6318-6334. Author URL.

Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.

Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Author URL.

Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Author URL.

Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, et al (2016). Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics, 48(1), 1-11. Author URL.

Tugay K, Guay C, Marques AC, Allagnat F, Locke JM, Harries LW, Rutter GA, Regazzi R (2016). Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets. Diabetologia, 59(1), 161-169. Author URL.

2015

Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying S-X, et al (2015). Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol, 70, 37-45. Author URL.

Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW, et al (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, 16(4), 423-434. Author URL.

Locke JM, Wei FY, Tomizawa K, Weedon MN, Harries LW (2015). A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia, 58(4), 745-748. Author URL.

Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere, 120, 555-562. Author URL.

Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci, 65(1), 145-150. Author URL.

Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW (2015). Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes, 64(4), 1484-1491. Author URL.

2014

Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Author URL.

Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Author URL.

Hogg DR, Harries LW (2014). Human genetic variation and its effect on miRNA biogenesis, activity and function. Biochem Soc Trans, 42(4), 1184-1189. Author URL.

Cipelli R, Harries L, Okuda K, Yoshihara S, Melzer D, Galloway T (2014). Bisphenol a modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction, 147(4), 419-426. Author URL.

Locke JM, Da Silva Xavier G, Dawe HR, Rutter GA, Harries LW (2014). Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia, 57(1), 122-128. Author URL.

2013

Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14. Author URL.

Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K (2013). A role for SPARC in the moderation of human insulin secretion. PLoS One, 8(6). Author URL.

Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW (2013). Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes, 121(7), 413-419. Author URL.

Locke JM, Lango Allen H, Harries LW (2013). A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetol, 51(2), 325-329. Author URL.

Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW (2013). Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev, 134(9), 356-366. Author URL.

Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW (2013). Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int, 57-58, 2-10. Author URL.

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Author URL.

Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW, et al (2013). Towards a gene expression biomarker set for human biological age. Aging Cell, 12(2), 324-326. Author URL.

2012

Fellows AD, Holly AC, Pilling LC, Melzer D, Harries LW (2012). Age related changes in mTOR-related gene expression in two primary human cell lines. Healthy Aging Research. Author URL.

Harries LW (2012). Long non-coding RNAs and human disease. Biochem Soc Trans, 40(4), 902-906. Author URL.

Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D (2012). Genomics and successful aging: grounds for renewed optimism?. J Gerontol a Biol Sci Med Sci, 67(5), 511-519. Author URL.

Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev, 133(8), 556-562. Author URL.

Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Author URL.

Morrison F, Johnstone K, Murray A, Locke J, Harries LW (2012). Oxidative metabolism genes are not responsive to oxidative stress in rodent beta cell lines. Experimental Diabetes Research, 2012. Author URL.

Garin I, de Nanclares GP, Gastaldo E, Harries LW, Rubio-Cabezas O, Castaño L (2012). Permanent neonatal diabetes caused by creation of an ectopic splice site within the INS gene. PLoS ONE, 7(1). Author URL.

Harries LW, Pilling LC, Hernandez LDG, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D, et al (2012). CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell, 11(2), 262-268. Author URL.

2011

Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (2011). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 119(12), 1788-1793. Author URL.

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research. Author URL.