- Claude Bernard -

“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

PUBLICATIONS

2020

 

 

2019

- Stuart R. G. Calimport, Barry L. Bentley, Claire E. Stewart, Graham Pawelec, Angelo Scuteri, Manlio Vinciguerra, Cathy Slack, Danica Chen, Lorna W. Harries, Gary Marchant, G. Alexander Fleming, Michael Conboy, Adam Antebi, Gary W. Small, Jesus Gil, Edward G. Lakatta, Arlan Richardson, Clifford Rosen, Karoly Nikolich, Tony Wyss-Coray, Lawrence Steinman, Thomas Montine, João Pedro de Magalhães, Judith Campisi, George Church. TO help aging populations, classify organismal senescence. Science 2019. Vol. 366, Issue 6465, pp. 576-578

- Harries LW. INVITED EDITORIAL. It’s time for scientists to shout about RNA therapies. Nature Outlook. October 2019

- Shahnaz Haque, Ryan M. Ames, Karen Moore, Luke C. Pilling, Luanne L. Peters, Stefania Bandinelli, Benjamin P. Lee, Luigi Ferrucci, and Lorna W Harries. CircRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan. GeroScience in Press Nov 2019

- Danny Galvis, Darren Walsh, Lorna W. Harries, Eva Latorre, James Rankin. A dynamical systems model for the measurement of cellular senescence J R Soc Interface. 2019 Oct 31;16(159):20190311

- Benjamin P. Lee, Lorna Mulvey, Gregory Barr, Jemma Garratt, Emily Goodman, Colin Selman, Lorna W. Harries. Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels. Exp Gerontol. 2019 Sep 12:110736.

 

- Jed J. Lye*, Eva Latorre*, Ben P. Lee, Stefania Bandinelli, Janet E. Holley, Nicholas J Gutowski, Luigi Ferrucci and Lorna W. Harries. Astrocyte senescence may drive alterations in GFAPa, CDKN2A p14ARF and TAU3 transcript expression and contribute to cognitive decline. Geroscience 2019 in press.

 

- Nicola Jeffery and Lorna W. Harries. miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC-βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways. Exp Cell Research 2019 in press.

- Benjamin P. Lee, Luke C. Pilling, Stefania Bandinelli, Luigi Ferrucci, David Melzer and Lorna W. Harries. The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with aging phenotypes in human peripheral blood. Biogerontology 2019 in press.

 

- Nicola Jeffery, Sarah Richardson, David Chambers, Noel G. Morgan, Lorna W. Harries. Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns. Human Molecular Genetics 2019 Aug 15;28(16):2763-2774. 

 

- Ari Meerson, Yaniv Eliraz, Hila Yehuda, Bridget Knight, Malcolm Crundwell, Douglas Ferguson, Benjamin P Lee and Lorna W Harries. Obesity impacts the regulation of miR-10b and its targets in primary breast tumors. BMC Cancer. 2019 Jan 18;19(1):86 

 

- Eva Latorre, Elizabeth L. Ostler, Richard G.A. Faragher and Lorna W. Harries. FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. FASEB J. 2019 Jan;33(1):1086-1097. 

2018

- Harries L, Goljanek-Whysall K. The biology of ageing and the omics revolution. Biogerontology. 2018 Dec;19(6):435-436.

- Tamara S Galloway, Nigel Baglin, Benjamin P Lee, Anna L Kocur, Maggie H Shepherd, Anna M Steele, BPA Schools Study Consortium, Lorna W Harries. An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol A (BPA) levels in teenagers. BMJ Open 2018; 8:e018742.

- Eva Latorre, Roberta Torregrossa, Mark E. Wood, Matthew Whiteman and Lorna W. Harries. Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2. Aging (Albany NY). 2018 Jul 19;10(7):1666-1681.

Locke JMSaint-Martin CLaver TWPatel KAWood ARSharp SAEllard SBellanné-Chantelot CHattersley ATHarries LW, Weedon MN. The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in HNF1A-MODY Individuals. Diabetes. 2018 Jun 12. pii: db180133. doi: 10.2337/db18-0133.

Galloway TSBaglin NLee BPKocur ALShepherd MHSteele AM, BPA Schools Study ConsortiumHarries LW.An engaged research study to assess the effect of a 'real-world' dietary intervention on urinarybisphenol A (BPA) levels in teenagers. BMJ Open. 2018 Feb 3;8(2):e018742. doi: 10.1136/bmjopen-2017-018742.

Latorre EPilling LCLee BPBandinelli SMelzer DFerrucci LHarries LW. The VEGFA165b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond). 2018 Jan 12. pii: CS20171556. doi: 10.1042/CS20171556.

2017

-Pilling LCAtkins JLDuff MOBeaumont RNJones SETyrrell JKuo CLRuth KSTuke MAYaghootkar HWood ARMurray AWeedon MNHarries LWKuchel GA6, Ferrucci LFrayling TMMelzer D.Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One. 2017 Sep 28;12(9):e0185083. doi: 10.1371/journal.pone.0185083.

Pilling LCKuo CLSicinski K, Tamosauskaite JKuchel GAHarries LWHerd PWallace RFerrucci LMelzer D. Human longevity: 25 genetic loci associated in 389,166 UK biobank participants. Aging (Albany NY). 2017 Dec 6;9(12):2504-2520. doi: 10.18632/aging.101334.

Haque SHarries LW. Circular RNAs (circRNAs) in Health and Disease. Genes. 2017 Nov 28;8(12). pii: E353. doi:

10.3390/genes8120353.

- Jeffery, N, Richardson, S, Beall, C, and Harries L.W. The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-bH1 cells. Exp Cell Res 2017 Dec 15;361(2):284-291.

- Latorre E, Vishal CB, Sheerin A, Jeynes CC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, Harries LW. Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biology 2017;18(1):31

- Latorre E and Harries LW. Splicing regulatory factors, ageing and age-related disease. Ageing Res Rev. 2017 Apr 26.

- Lee BP, Buric I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW. MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep 2017 Mar 17;7-44620

 

2016

- Jeffery N and Harries LW. β-cell differentiation status in type 2 diabetes. Diabetes Obes Metab. 2016 Aug 23. 

- Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG, Rajan P, Elliott DJ. Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine. 2016 Jun;8:103-16.

- Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW. Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell. 2016 Jun 30. doi: 10.1111/acel.12499. [Epub ahead of print].

- Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N. The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res. 2016 Jun 24. pii: gkw565. [Epub ahead of print].

- Janice Atkins, Luke Pilling, Alessandro Ble, Ambarish Dutta, Lorna Harries, Anna Murray, Carol Brayne, Jean-Marie Robine, George Kuchel, Luigi Ferrucci, David Melzer. Longer-lived parents and cardiovascular outcomes: 8 year follow-up in 186,000 UK biobank participants. Journal of the American College of Cardiology, 2016 in press.

- Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Murray A, Weedon MN, Xue L, Lunetta K, Murabito JM, Harries LW, Robine JM, Brayne C, Kuchel GA, Ferrucci L, Frayling TM, Melzer D. Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY). 2016 Mar;8(3):547-63.

- Lee BP, Lloyd Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW. Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol. 2016 Mar 17. S0303-7207(16)30068-5.

- Pilling LC, Joehanes R, Kacprowski T, Peters MJ, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell JE, Levy D, Lin H, Lunetta K, Munson PJ, Bandinelli S, Henley WE, Hernandez DG, Singleton AB, Tanaka T, van Grootheest G, Hofman A, Uitterlinden AG, Biffar R, Gläser S, Homuth G, Malsch C, Völker U, Penninx BW, van Meurs JB, Ferrucci L, Kocher T, Murabito JM, Melzer D. Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics. 2016 Jan;48(1):1-11.

- Ksenia Tugay, Claudiane Guay, Ana Claudia Marques, Florent Allagnat, Jonathan Locke, Lorna W. Harries, Guy A. Rutter and Romano Regazzi. Role of miRNAs in age-associated decline of pancreatic beta cell function. Diabetologia. 2016 Jan;59(1):161-9.

- Luke C. Pilling,1, Roby JoehanesDavid MelzerLorna W. HarriesWilliam HenleyJosée DupuisHonghuang LinMarcus Mitchell Dena Hernandez, Sai-Xia Ying, Kathryn L. Lunetta, Emelia J Benjamin, Andrew Singleton, Daniel Levy, Peter Munson, Joanne M. Murabito, Luigi Ferrucci. Gene expression markers of age-related inflammation in Two Human Cohorts. Exp Gerontol. 2015 Oct;70:37-45.

2015

- Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW. Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology. 2015 Aug;16(4):423-34.

- Locke JM, Wei FY, Tomizawa K, Weedon MN, Harries LW. A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia. 2015 Apr;58(4):745-8.

- Tamara S. Galloway, Tony Fletcher, David Melzer, Oliver J. Thomas, Ben P. Lee, Luke Pilling and Lorna W. Harries. Associations between exposure to PFOA, PFOS, Osteoarthritis and the parathyroid hormone signalling pathway. Chemosphere. 2015 Feb;120:555-62.

- Jamie Blackwell, Lorna W. Harries (Joint first author), Luke C. Pilling, Luigi Ferrucci, Andrew Jones, David Melzer. Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci. 2015 Jan;65(1):145-50. 

- Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW. Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes. 2015 Apr;64(4):1484-91.

2014

- Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, Condliffe D, Harries LW, Katsel P, Haroutunian V, Kaminsky Z, Joachim C, Powell J, Lovestone S, Bennett DA, Schalkwyk LC, Mill J. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci. 2014 Aug 17. doi: 10.1038/nn.3782. 

- Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW. Splicing Factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev. 2014 

- Lorna W. Harries. MicroRNAs as mediators of the ageing process. Genes 2014, 5(3),656-670. 

- Hogg, D and Harries LW. Human genetic variation and its effect on miRNA biogenesis, activity and function. INVITED REVIEW. Biochem Soc Trans. 2014 Aug 1;42(4):1184-9.

- Cipelli R, Harries L* (joint first author), Okuda K, Yoshihara S, Melzer D, Galloway T. Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction. 2014 Mar 2;147(4):419-26.

- Locke JM, da Silva Xavier G, Dawe HR, Rutter GA, Harries LW. Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia. 2014 Jan;57(1):122-8. 

2013

- Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW. The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics. 2013 Sep 17;14(1):627.

- Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K. A role for SPARC in the moderation of human insulin secretion. PloS One. 2013 Jun 28;8(6):e68253. 

- Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW. Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes. 2013 Jul;121(7):413-9. 

- Locke JM, Lango Allen H, Harries LW. A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetol. 2013 Jul 5. 

- Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW. Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev. 2013 Jun 6. Doi:pii: S0047-6374(13)00065-1.

- Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW. Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int. 2013 Jul;57-58:2-10. 

- Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR. Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea Hyperb Med. 2013 Mar-Apr;40(2):115-23. 

- Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW. Towards a gene expression biomarker set for human biological age. Aging Cell. 2013 Apr;12(2):324-6. 

- Faer Morrison, Jonathan Locke, Anna Murray, Lorna W. Harries. Expression profiling of putative Type 2 diabetes susceptibility genes in human islets and in rat beta cell lines. J Diabetes Mellitus, Vol.3, No.1, 27-32 (2013).

2012

- Alexander D. Fellows, Alice C. Holly, Luke C. Pilling, David Melzer, Lorna W. Harries. Age related changes in mTOR-related gene expression in two primary human cell lines. Healthy Aging Research 2012, 1:3 

- Harries LW. Long non-coding RNAs and human disease. INVITED REVIEW Biochem Soc Trans. 2012 Aug;40(4):902-6.

- Pilling LC, Harries LW (joint first author), Powell J, Llewellyn DJ, Ferrucci L, Melzer D. Genomics and Successful Aging: Grounds for Renewed Optimism? INVITED REVIEW J Gerontol A Biol Sci Med Sci. 2012 Mar 27.

- Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D. Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. Mech Ageing Dev. 2012 Aug;133(8):556-62. 

- Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, Ferrucci L, Melzer D. Leukocyte CCR2 Expression Is Associated with Mini-Mental State Examination Score in Older Adults. Rejuvenation Res. 2012 2012 Aug;15(4):395-404. 

- Melzer D, Harries L* (Joint first author), Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Galloway T. Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect. 2011  Dec;119(12):1788-93. 

- Morrison F, Johnstone K, Murray A, Locke J, Harries LW. Oxidative metabolism genes are not responsive to oxidative stress in rodent Beta cell lines. Exp Diabetes Res. 2012;2012:793783. 

- Intza Garin, Guiomar Perez de Nanclares, Elena Gastaldo, Lorna W Harries, Luis Castaño. Permanent neonatal diabetes caused by ectopic splice site at the INS gene. PloS One. 2012;7(1):e29205. 

- Harries LW, Pilling LC, Hernandez LD, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D. CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell. 2012 Apr;11(2):262-268.

- Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P. Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Exp. Cell Res 2012 Feb 1;318(3):207-16.

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