Gene expression analysis reveals a 5-gene signature for progression-free survival in prostate cancer
Prostate cancer (PCa) is the second most common male cancer worldwide, but effective biomarkers for the presence or progression risk of...
Plastic chemical 'in 86% of teens'
Objective Bisphenol A (BPA) has been associated with adverse human health outcomes and exposure to this compound is near-ubiquitous in...
Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels
The rs2802292, rs2764264 and rs13217795 variants of FOXO3 have been associated with extreme longevity in multiple human populations, but...
New COVID-19 tests determines how long people remain infectious
Prevention of ongoing transmission of SARS-CoV-2 is an essential component of managing the current pandemic. A key prerequisite for this...
Using RNA splicing factors to predict future health outcomes
This research follows on from some of our earlier work on alternative RNA splicing, and builds on our findings that the regulators of the...
To β or not to β: Beta cell identity in Diabetes
Work using mice and rats has shown that when exposed to the kinds of physiological conditions seen in a person with type 2 diabetes, the...
Upregulation of splicing regulatory factor expression is associated with senescence rescue
Our results suggest that modification of splicing factor expression has the potential to influence cell senescence phenotypes and could...
The Role of RNA in Longevity
This research thread focuses on the role of RNA regulation in ageing and longevity in mammals. We are currently investigating two...
Beta cell changes in Type 2 Diabetes
Type 2 Diabetes affects 415 million people world-wide and is characterised by chronic high blood sugar (hyperglycaemia) and insulin...