
Image Analysis Using the Fluorescence Imaging of Nuclear Staining (FINS) Algorithm
Finding appropriate image analysis techniques for a particular purpose can be difficult. In the context of the analysis of...

Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones
Repurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency...


Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer
Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a hallmark of cancer that profoundly...


Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes
Progeroid syndromes such as Hutchinson Gilford Progeroid syndrome (HGPS), Werner syndrome (WS) and Cockayne syndrome (CS), result in...


Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence
The human genome is capable of producing hundreds of thousands of different proteins and non-coding RNAs from <20 000 genes, in a...


An evaluation of the role of miR-361-5p in senescence and systemic ageing
Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery...


Gene expression analysis reveals a 5-gene signature for progression-free survival in prostate cancer
Prostate cancer (PCa) is the second most common male cancer worldwide, but effective biomarkers for the presence or progression risk of...


Plastic chemical 'in 86% of teens'
Objective Bisphenol A (BPA) has been associated with adverse human health outcomes and exposure to this compound is near-ubiquitous in...


Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels
The rs2802292, rs2764264 and rs13217795 variants of FOXO3 have been associated with extreme longevity in multiple human populations, but...

New COVID-19 tests determines how long people remain infectious
Prevention of ongoing transmission of SARS-CoV-2 is an essential component of managing the current pandemic. A key prerequisite for this...